Endocrine Abstracts

Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This response is associated with interruption of gap junctional communication (GJC) within the ovarian follicle and can be reversed by elevation of intraoocyte cAMP. In the present study, we examined the hypothesis that termination of cellular communication in the ovarian follicle is sufficient for induction of oocyte maturation. To test our hypothesis we used rat follicle-enclosed oocytes (FEO) tha...